HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1057508Generated: October 26, 2026
2-Bromo-5-nitrobenzoic acid → (2-Bromo-5-nitrophenyl)methanol
https://huagongshe.com/reaction/1057508
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromo-5-nitrobenzoic acid | HCID 243025 | — |
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (2-Bromo-5-nitrophenyl)methanol | HCID 18671373 | — |
Reaction Steps
To a stirring solution of 2-bromo-5-nitrobenzoic acid (1 eq) in tetrahydrofuran (0.4 M) at 0° C. under nitrogen was added BH3/THF (1 M) (1.5 eq). The reaction mixture was stirred at 70° C. for 1 hr and quenched with methanol. The reaction mixture was concentrated in vacuo to afford the product. EI-MS m/z 232 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06514964B1 |
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| Source dataset | uspto-grants-2003_02 |
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| ORD ID | ord-098594bda92d4387b2300d3a238bbc1a |
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| Source note | uspto-grants-2003_02 |
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