Hydrochloride methanol → 4-[(4-Methyl-5-isoquinolyl)oxy]piperidine hydrochloride

HRID 10576Notes

Reaction equation

HRID 10576 reaction equation
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:5]=[N:4][CH:3]=1.[ClH:26].CO>>[ClH:26].[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 21979903HCID 21979903, compound

Product 1

HCID 219797864-[(4-Methyl-5-isoquinolyl)oxy]piperidine hydrochloride

Procedure

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 128 (604 mg) and 10% hydrogen chloride/methanol solution (20 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (5 ml) and diethyl ether (15 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (513 mg).

Workup

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (5 ml) and diethyl ether (15 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-e0052dc7514340f6aa87ab5a0aa5366d
Source dataset
uspto-grants-2006_08
Patent number
US07094789B2

Reaction notes

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