Trifluoroacetic acid → HCID 9843118, compound

Participants

Reaction Steps

A mixture of tert-Butyl 4-{2-[(9-Benzyl-9H-carbazol-4-yl)oxy]ethyl}-1-piperazinecarboxylate (0.0450 g, 0.0927 mmol), trifluoroacetic acid (2.5 mL), and CH2Cl2 (2.5 mL) is stirred at room temperature for 1 h. Trifluoroacetic acid and CH2Cl2 are then removed in vacuo and the residue is partitioned between CH2Cl2 and aq. sodium bicarbonate. The organic layers are dried over sodium sulfate and taken to dryness to give 0.0326 g (91%) of the title compound; IR (drift) 2935, 2821, 1584, 1456, 1353, 1342, 1332, 1271, 1245, 1154, 1145, 1112, 783, 750, 715 cm−1; 1H NMR (CDCl3) δ2.70, 2.95, 3.04, 4.41, 5.50, 6.69, 6.99, 7.12, 7.2-7.4, 8.39. Anal. Calcd for C25H27N3O: C, 77.89; H, 7.06; N, 10.90. Found: C, 76.35; H, 7.20; N, 10.30.

Provenance & Evidence