HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → (R)-1-(1-Phenylethylamino)-4-(4-pyridylmethyl)phthalazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | 1-Phenethylamine, (-)- | HCID 75818 | — |
| Reactant | 1-Chloro-4-(4-pyridinylmethyl)phthalazine | HCID 1944609 | — |
| Solvent | Water | HCID 962 | — |
| Product | (R)-1-(1-Phenylethylamino)-4-(4-pyridylmethyl)phthalazine dihydrochloride | HCID 69837621 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine, 1.273 ml (10 mmol) (S)-1phenylethylamine and 5 ml 1-butanol is stirred for 40 h at 110° C. After processing as described in Example 12 and equilibration for 65 hours at 20° C. and in room atmosphere, title compound is obtained with a water content of 10.53%; m.p. 190° C. (decomp.); ESI-MS: (M+H)+=341; [a]D20=+38.4±0.7° (c=1.507%, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514974B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-f082250128254c5aa284b3b6e5688d4b |
| Source note | uspto-grants-2003_02 |