HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → 7-Acetamino-1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | 7-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine | HCID 22741951 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 7-Acetamino-1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride | HCID 22741998 | — |
Reaction Steps
Under exclusion of air, 207 mg (0.66 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine is heated to boiling for 4 h in 2.7 ml 1-butanol with 253 mg (1.98 mmol) 4-chloroaniline. After cooling, the dark suspension is filtered off, washed with 1-butanol and ethanol, and dried to obtain title compound: m.p.: 260-265° C.; HPLC: tRet(Grad5-40)=10.9; FAB MS (M+H)+=404.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514974B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-31c0177c2164484384efb1ae4ae41d79 |
| Source note | uspto-grants-2003_02 |