Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloroaniline → 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloroaniline | HCID 7932 | — |
| 반응물 | 7-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine | HCID 22741951 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | 7-Acetamino-1-(3-chloroanilino)-4-(4-pyridylmethyl)phthalazine hydrochloride | HCID 22742013 | — |
반응 단계
By analogy with Example 25, 300 mg (0.96 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine is reacted in 3.9 ml 1-butanol with 302 μl (2.88 mmol) 3-chloroaniline. Suspension of the raw product in 1 ml boiling ethanol and filtration lead to the title compound: HPLC: tRet(Grad5-40)=11.3; FAB MS (M+H)+=404.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06514974B2 |
| 출처 데이터셋 | uspto-grants-2003_02 |
| ORD ID | ord-8074b467526343b2b9686f41f3be898b |
| 출처 메모 | uspto-grants-2003_02 |