Succinic Acid → Vatalanib Succinate

Participants

Reaction Steps

A solution of 1.77 g (15 mmol) succinic acid in 35 ml ethanol is added to a hot solution of 5.0 g (14.4 mmol) 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine in 150 ml ethanol. As the mixture cools (scraping) to 0° C., a crystalline precipitate slowly forms, which is filtered off, washed with ethanol, and dried: Anal. calc.(C24H21N4ClO4) C, 62.00%; H, 4.55%; N, 12.05%; found C, 62.02%; H, 4.75%; N, 12.04%.

Provenance & Evidence