Hydrazine hydrate (1:1) → 4-(4-pyrimidinylmethyl)-1(2H)-phthalazinone

Participants

Reaction Steps

1.20 g (5.35 mmol) 2-pyrimidin-4-yl-indan-1,3-dione in 30 ml ethanol is spiked with 345 μl (6.96 mmol) hydrazine hydrate and heated for 5 h to 100° C. After cooling, the product is filtered off and washed with ethanol: m.p.: 204-206° C.; Anal. calc.(C13H10N4O.0.5 H2O) C, 63.15%; H, 4.48%; N, 22.66%; found C, 63.3%; H, 4.5%; N, 22.7%; FAB MS (M+H)+=239.

Provenance & Evidence