Hydrogen Bromide → HCID 23658369, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1M HBr in EtOH (0.5 mL) was added N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (190 mg, 0.5 mmol, 1 eq) then cooled to -40° C. overnight. The solid precipitate that formed was collected on a Buchner funnel, washed with absolute EtOH then dried under vacuum at 100° C. to afford the title compound (72%) as a fine white powder, mp 235-237° C. Analysis calc'd for C17H24N4O2S2.HBr: C, 44.24; H, 5.46; N, 12.14; S, 13.89; Br, 17.31. Found: C, 44.16; H, 5.40; N, 12.12; S, 13.91; Br, 17.70.

Provenance & Evidence