HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 18672149, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Chloro-1,2-oxazole-3-carboxylic acid | HCID 22311430 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 18672149 | HCID 18672149 | — |
Reaction Steps
A solution of 5-chloroisoxazole-3-carboxylic acid (0.750 g, 4.32 mmol, 1 equiv) and thionyl chloride (9.0 mL, 120 mmol, 28 equiv) in CHCl3 (21 mL) was heated to reflux for 28 h. The volatiles were evaporated to provide a residue which was dissolved in benzene (40 mL), which was subsequently evaporated to give the title intermediate as a yellow oil which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514997B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-f5a5e3c3c9ae47b288f38cd46aaac984 |
| Source note | uspto-grants-2003_02 |