4'-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrile → Tert-butyl 1-{3-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]propyl}-3-pyrrolidinylcarbamate

HRID 1057774Notes

Reaction equation

HRID 1057774 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:3]1.N1(N[C:31](=[O:37])[O:32][C:33]([CH3:36])([CH3:35])[CH3:34])CCCC1>>[C:23]([C:20]1[CH:19]=[CH:18][C:17]([C:14]2[CH:15]=[CH:16][C:11]([O:10][CH2:9][CH2:8][CH2:7][N:4]3[CH2:5][CH2:6][CH:2]([NH:1][C:31](=[O:37])[O:32][C:33]([CH3:36])([CH3:35])[CH3:34])[CH2:3]3)=[CH:12][CH:13]=2)=[CH:22][CH:21]=1)#[N:24]

Participants

3

Reactant 2

HCID 99231474'-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1'-biphenyl]-4-carbonitrileHCID 21959621Tert-butyl pyrrolidin-1-ylcarbamate

Product 1

HCID 10180520Tert-butyl 1-{3-[(4'-cyano[1,1'-biphenyl]-4-yl)oxy]propyl}-3-pyrrolidinylcarbamate

Procedure

4′-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1′-biphenyl]-4-carbonitrile and tert-butyl pyrrolidinylcarbamate were processed as described in Examples 9A-9C to provide the title compound.

Sources & evidence

ORD record
ord-d3a18150282249a1b728cfb5a9c73d15
Source dataset
uspto-grants-2003_02
Patent number
US06515013B2

Reaction notes

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