HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichlorobenzene → 4-allyl-5-hydroxy-N-neopentylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichlorobenzene | HCID 7239 | — |
| Reactant | 5-allyloxy-N-neopentylindole | HCID 18672460 | — |
| Product | 4-allyl-5-hydroxy-N-neopentylindole | HCID 18672464 | — |
Reaction Steps
5-Allyloxy-N-neopentylindole (Step B; 1.4 g, 4.93 mmol) was refluxed in 20 mL 1,2-dichlorobenzene for 4 hours. The reaction mixture was cooled and immediately purified by flash chromatography on silica gel (gradient elution: hexane then 10% ethyl acetate/hexane) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06515015B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-9c5ee24b9dfd4ffc8b14f8e6ac987a43 |
| Source note | uspto-grants-2003_02 |