HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1,2-Dimethoxyethane → 3-(3,5-Di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1,2-Dimethoxyethane | HCID 8071 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-Bromo-2,6-di-tert-butylphenol | HCID 70829 | — |
| Edukt | 5-Formyl-2-methoxyphenylboronic acid | HCID 2734367 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 3-(3,5-Di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde | HCID 22268285 | 61% |
Reaktionsschritte
The intermediate 3-(3,5-di-t-butyl-4-hydroxyphenyl)-3-methoxybenzaldehyde was prepared in a manner similar to the procedure described in Example 1b using 4-bromo-2,6-di-t-butylphenol (0.50 g, 1.75 mmol), 2-methoxy-5-formylphenyl boronic acid (0.315 g, 1.75 mmol), tetrakis(triphenylphosphine)palladium(0) (0.20 g, 0.175 mmol), K2CO3 (0.95 g, 7.0 mmol), dimethoxyethane (15 mL) and H2O (1 mL); 367 mg, 61% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06515003B1 |
| Quelldatensatz | uspto-grants-2003_02 |
| ORD ID | ord-d7d8896bb86746f2825ff376009324df |
| Quellennotiz | uspto-grants-2003_02 |