4-Chlorobenzylamine → (+/-)-3-[(4-Chlorobenzyl)aminocarbonyl]methyl-4-[(3,5-dichloro-4-pyridyl)aminocarbonyl]-7-methoxy-2,3-dihydro-benzofuran

HRID 1057877Notes

Reaction equation

HRID 1057877 reaction equation
[C:1]([CH2:4][CH:5]1[C:9]2[C:10]([C:16]([NH:18][C:19]3[C:24]([Cl:25])=[CH:23][N:22]=[CH:21][C:20]=3[Cl:26])=[O:17])=[CH:11][CH:12]=[C:13]([O:14][CH3:15])[C:8]=2[O:7][CH2:6]1)([OH:3])=O.[Cl:27][C:28]1[CH:35]=[CH:34][C:31]([CH2:32][NH2:33])=[CH:30][CH:29]=1>>[Cl:27][C:28]1[CH:35]=[CH:34][C:31]([CH2:32][NH:33][C:1]([CH2:4][CH:5]2[C:9]3[C:10]([C:16]([NH:18][C:19]4[C:24]([Cl:25])=[CH:23][N:22]=[CH:21][C:20]=4[Cl:26])=[O:17])=[CH:11][CH:12]=[C:13]([O:14][CH3:15])[C:8]=3[O:7][CH2:6]2)=[O:3])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 660364-ChlorobenzylamineHCID 22734342(+/-)-3-Carboxymethyl-4-(3,5-dichloro-4-pyridylamino-carbonyl)-7-methoxy-2,3-dihydrobenzofuran

Product 1

HCID 22734023(+/-)-3-[(4-Chlorobenzyl)aminocarbonyl]methyl-4-[(3,5-dichloro-4-pyridyl)aminocarbonyl]-7-methoxy-2,3-dihydro-benzofuranYield 58%

Procedure

Substantially the same procedure as in Example 13 was repeated using Compound 9 (0.20 g) obtained in Example 9 and 4-chlorobenzylamine to give Compound 30 (0.15 g, 58%) as a white solid.

Sources & evidence

ORD record
ord-7ee5e67af0804389ba3242023c6d107d
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

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