Sodium Hydroxide → HCID 22734155, compound

HRID 1057889Notes

Reaction equation

HRID 1057889 reaction equation
C([O:3][C:4](/[CH:6]=[CH:7]/[C:8]1[C:13]2[CH2:14][C:15]3([O:20][C:12]=2[C:11]([O:21][CH3:22])=[CH:10][CH:9]=1)[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:5])C.[OH-].[Na+]>C(O)C>[C:4](/[CH:6]=[CH:7]/[C:8]1[C:13]2[CH2:14][C:15]3([O:20][C:12]=2[C:11]([O:21][CH3:22])=[CH:10][CH:9]=1)[CH2:16][CH2:17][CH2:18][CH2:19]3)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22733995HCID 22733995, compound

Product 1

HCID 22734155HCID 22734155, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of Compound 90a (3.5 g) obtained in Step A, a 4N aqueous solution (35.0 ml) of sodium hydroxide, and ethanol (150 ml) was stirred at room temperature for 15 hours. The solvent was distilled off and the residue was dissolved in water. Concentrated hydrochloric acid was dropwise added to the solution, and a precipitate was collected by filtration, washed with water, and dried to give Compound 90b (2.38 g, 74.9%) as white crystals.

Workup

  1. distillationThe solvent was distilled off
  2. dissolutionthe residue was dissolved in water
  3. additionConcentrated hydrochloric acid was dropwise added to the solution
  4. filtrationa precipitate was collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-735b4f41f3b94398aaa5b60a013a82c7
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

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