Sodium Hydroxide → HCID 22734267, compound

HRID 1057897Notes

Reaction equation

HRID 1057897 reaction equation
[CH3:1][C:2]1([CH3:23])[CH2:6][C:5]2[C:7]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([O:21]C)=[O:20])=[CH:15][CH:14]=3)=[CH:8][CH:9]=[C:10]([O:11][CH3:12])[C:4]=2[O:3]1.[OH-].[Na+]>C(O)C>[C:19]([C:16]1[CH:15]=[CH:14][C:13]([C:7]2[C:5]3[CH2:6][C:2]([CH3:1])([CH3:23])[O:3][C:4]=3[C:10]([O:11][CH3:12])=[CH:9][CH:8]=2)=[CH:18][CH:17]=1)([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22734119HCID 22734119, compound

Product 1

HCID 22734267HCID 22734267, compoundYield 85.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of Compound 144 (1.0 g) obtained in Example 144, a 4N aqueous solution (8.0 ml) of sodium hydroxide, and ethanol (40 ml) was stirred at room temperature for 4 hours. The solvent was removed and the residue was dissolved in water. Concentrated hydrochloric acid was dropwise added to the solution, and the generated precipitate was collected by filtration, washed with water, and dried to give Compound 145 (0.82 g, 85.9%) as white crystals.

Workup

  1. customThe solvent was removed
  2. dissolutionthe residue was dissolved in water
  3. additionConcentrated hydrochloric acid was dropwise added to the solution
  4. filtrationthe generated precipitate was collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-08529175548e458681727e8590911921
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

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