Methylamine hydrochloride → HCID 22734360, compound

HRID 1057913Notes

Reaction equation

[CH:1]1([NH:5][C:6]([C:8]2[O:9][C:10]3[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([CH:19]=O)[C:11]=3[CH:12]=2)=[O:7])[CH2:4][CH2:3][CH2:2]1.Cl.[CH3:22][NH2:23]>>[CH:1]1([NH:5][C:6]([C:8]2[O:9][C:10]3[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([CH2:19][NH:23][CH3:22])[C:11]=3[CH:12]=2)=[O:7])[CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 22734466HCID 22734466, compound

Product 1

HCID 22734360HCID 22734360, compound

Procedure

Substantially the same procedure as in Example 219 was repeated using a starting material, 7-methoxybenzofuran-2-carboxylic acid, and cyclobutylamine to give N-Cyclobutyl-7-methoxybenzofuran-2-carboxamide (Compound 289a). Successively, it was formylated to give N-cyclobutyl-4-formyl-7-methoxybenzofuran-2-carboxamide (Compound 289b), then compound 289b was reacted with methylamine hydrochloride to give Compound 289 as a white solid.

Sources & evidence

ORD record: ord-0dd1aa5a33744857a81b8c37f7c46e4d
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06514996B2

Reaction notes

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