HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloroaniline → N-(4-chlorophenyl)-7-methoxybenzofuran-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloroaniline | HCID 7812 | — |
| Reactant | 7-Methoxy-1-benzofuran-2-carboxylic acid | HCID 606037 | — |
| Product | N-(4-chlorophenyl)-7-methoxybenzofuran-2-carboxamide | HCID 22734372 | — |
Reaction Steps
Substantially the same procedure as in Example 219 was repeated using a starting material, 7-methoxybenzofuran-2-carboxylic acid, and 4-chloroaniline to give N-(4-chlorophenyl)-7-methoxybenzofuran-2-carboxamide (Compound 379a). Successively, it was formylated to give N-(4-chloropheny)-4-formyl-7-methoxybenzofuran-2-carboxamide (Compound 379b), then compound 379b was reacted with cyclobutylamine to give compound 379 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06514996B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-61932a9d646348bf8cb340863748d424 |
| Source note | uspto-grants-2003_02 |