2-Iodo-6-methoxyphenol → HCID 13902149, compound

HRID 1057937Notes

Reaction equation

HRID 1057937 reaction equation
[I:1][C:2]1[C:7]([OH:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][CH:3]=1.Br[CH2:12]/[CH:13]=[CH:14]/[C:15]([O:17][CH2:18][CH3:19])=[O:16]>>[I:1][C:2]1[C:7]([O:8][CH2:12]/[CH:13]=[CH:14]/[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 4437372-Iodo-6-methoxyphenolHCID 5373944Ethyl (E)-4-bromobut-2-enoate

Product 1

HCID 13902149HCID 13902149, compound

Procedure

Substantially the same procedure as in Step A of Reference Example 1 was repeated using 6-iodo-2-methoxyphenol [Heterocyclic Communications, 289 (1995)] (0.4 g) and ethyl 4-bromocrotonate (0.29 ml) to give Compound IIbc-a (0.52 g, 90%) as a pale-yellow oily substance.

Workup

  1. customto give Compound IIbc-a (0.52 g, 90%) as a pale-yellow oily substance

Sources & evidence

ORD record
ord-5e403c03bb224fb1b8ee4834aadcb93a
Source dataset
uspto-grants-2003_02
Patent number
US06514996B2

Reaction notes

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