Chloromethyl Methyl Ether → HCID 22634644, compound

HRID 1057970Notes

Reaction equation

HRID 1057970 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]2[C:19]([CH3:20])=[CH:18][C:17]3[C:16]([CH3:22])([CH3:21])[CH2:15][CH2:14][C:13]([CH3:24])([CH3:23])[C:12]=3[CH:11]=2)=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:25][O:26][CH2:27]Cl>>[CH3:25][O:26][CH2:27][O:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]2[C:19]([CH3:20])=[CH:18][C:17]3[C:16]([CH3:22])([CH3:21])[CH2:15][CH2:14][C:13]([CH3:24])([CH3:23])[C:12]=3[CH:11]=2)=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

3

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 22634654HCID 22634654, compound

Product 1

HCID 22634644HCID 22634644, compoundYield 102.7%

Procedure

In a similar manner to Example 10(b), by reaction of 3 g (9.3 mmol) of 2-hydroxy-5-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl) benzaldehyde [prepared in Example 16(a)] with 777 μl (10.2 mmol) of methoxymethyl chloride, 3.5 g (100%) of the expected product are obtained in the form of an oil.

Sources & evidence

ORD record
ord-0b26d1086dd7403daa60b90472eafedd
Source dataset
uspto-grants-2003_02
Patent number
US06515021B1

Reaction notes

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