3-Nitrophthalic anhydride → HCID 792946, compound

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Reaction Conditions

Reaction Steps

386 mg of 3-nitrophthalic anhydride and 242 mg of (S)-α-methylbenzylamine were charged in an egg-plant type flask of 50 ml, followed by stirring under heating at a temperature of 180° C. for 1.5 hours. After cooled, the reaction product was dissolved in chloroform, purified by silica gel column chromatography (eluent; methylene chloride:methanol=30:1 v/v), recrystallized from a mixed solvent of n-hexane-ethyl acetate, to obtain 443 mg of the desired product as a light yellow powder. Yield: 75%. m.p. 115-117° C.; MS(EI+) 296(M) Representative examples of the compounds of the present invention synthesized based on the Synthesis Examples or the methods for producing the compounds of the present invention as mentioned above, are listed in Table 1.

Provenance & Evidence