HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyridine → 2-(N-Methyl-N-(2-pyridyl)amino)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyridine | HCID 7977 | — |
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Product | 2-(N-Methyl-N-(2-pyridyl)amino)ethanol | HCID 737420 | — |
Reaction Steps
The reaction of 2-chloropyridine with 2-(N-methyl amino)ethanol provides 2-(N-methyl-N-(2-pyridyl)amino)ethanol (II), which on coupling reaction with 4-fluorobenzaldehyde (III) in an aprotic polar solvent with an alkali metal hydroxide or an alkali metal alkoxide as base yields 4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzaldehyde (IV) with an 88% yield (Reaction I).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06515132B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-e58b72df1612415e90e00bb4f473b1d1 |
| Source note | uspto-grants-2003_02 |