Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 3-(Piperidin-4-yl)propanoic acid | HCID 1520806 | — |
| Reactant | Calcium Hydroxide | HCID 6093208 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 9895314 | HCID 9895314 | 95% |
Reaction Steps
3-(4-Piperidyl)propionic acid (20.0 g, 0.12 mol) and calcium hydroxide (14.1 g, 0.19 mol) were suspended in 47 g water and 195 g acetonitrile at 15-25° C. and then cooled to 0-10° C. Benzyl chloroformate (23.9 g, 0.14 mol) was added within 30 minutes and the reaction stirred at 0-5° C. for 2 h. The product precipitated during the reaction and was isolated by filtration to afford the title compound in 95% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06515130B1 |
|---|
| Source dataset | uspto-grants-2003_02 |
|---|
| ORD ID | ord-d4966a7f3421429b9eaf8065ae2d54d4 |
|---|
| Source note | uspto-grants-2003_02 |
|---|
