HCID 23000581, compound → HCID 59038209, compound

Participants

Reaction Steps

The title compound was prepared from 2-(2-(tert-butoxycarbonylamino)ethyl)-5-chlorobenzyl amine from Step 4 and N-(tert-butoxycarbonyl)-3-pyridin-2-yl-D-alanyl-L-proline from Step 5 using a similar coupling, deprotection, and purification procedures as described in Steps 7 and 8 of Example 15: 1H NMR (DMSO-d6, 400 MHz): δ 8.84 (t, 1H, J=5.8 Hz), 8.72-8.62 (br m, 4H), 8.12-8.00 (br m, 4H), 7.54 (d, 2H, J=7.9 Hz), 7.33-7.19 (m, 4H), 4.58 (br s, 1H), 4.40-4.20 (m, 3H), 3.88-3.80 (m, 2H), 3.43-3.28 (m, 3H), 2.96 (br s, 4H), 1.90-1.75 (br m, 2H); MS (Electrospray): M+H=430.2; TLC Rf=0.13 (80/10/1 of methylene chloride/methanol/concentrated ammonium hydroxide).

Provenance & Evidence