1,2-Dichloroethane → HCID 12021269, compound

Participants

Reaction Steps

EDC (49.5, 0.26 mmol) was added to a stirred mixture of N-{5-chloro-2-[(3-hydroxyazetidin-1-yl)methyl]benzyl}-L-prolinamide (55.8 mg, 0.17 mmol), 9-hydroxy-9-H-fluoren-9-ylcarboxylic acid (40.9 mg, 0.18 mmol) and HOAT (11.7 mg, 0.086 mmol) in DMF (1.25 mL). After 16 h the mixture was concentrated and the residue was partitioned between EtOAc and 10% NaHCO3. The organic layer was washed with water and brine, dried (Na2SO4) and evaporated. The residue was purified by chromatography on silica (ammonia saturated CHCl3/MeOH, 98:2) to give the title compound as a glass: HRMS (FAB) calcd C30H31ClN3O4 (M+1) 554.1817, found 554.1855.

Provenance & Evidence