HCID 18672287, compound → 3-Phenylpyrrolidine-2-carboxylic acid

Participants

Reaction Steps

3-Phenyl-D,L-proline was prepared from diethyl-3-phenylpyrrolidine-2,2-dicarboxylate (2.82 g, 9.70 mmol) essentially according to the procedure described in U.S. Pat. No. 4,060,603 for the preparation of 3,3-dimethyl-D,L-proline from 2,2-dicarboethoxy-3,3-dimethylpyrrolidine. The product was isolated as a brown oil. LCMS RT=0.62 min. LCMS (M+H)=191.9. 1H NMR (CD3OD, 400 MHz): δ 7.36-7.28 (m, 5H), 4.60 (d, J=9.2 Hz, 1H), 3.97 (apparent q, J=8.4 Hz, 1H), 3.77-3.71 (m, 1H), 3.48-3.41 (m, 1H), 2.58-2.50 (m, 1H), 2.43-2.33 (m, 1H).

Provenance & Evidence