Sulfuryl chloride → HCID 18673018, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl isobutyrylacetate (2 g, 12.6 mmol) in dichloromethane (12 mL) at 0° C. was added a 1M solution of sulfuryl chloride in dichloromethane (13.9 mL, 13.9 mmol). The reaction mixture was warmed to 25° C. and stirred for 2.5 h. The reaction mixture was diluted with dichloromethane (80 mL) and washed in turn with water (2×60 mL) and brine (75 mL). The organic extract was dried (MgSO4), filtered, concentrated to yield ethyl 2-chloroisobutyrylacetate (2.8 g, 66% product, 34% ethyl isobutyrylacetate) as a yellow oil which was used as is in the step below.

Provenance & Evidence