HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Methylbenzyl)-2-thiourea → HCID 86583842, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Methylbenzyl)-2-thiourea | HCID 1810724 | — |
| Reactant | Methyl 4-(2-bromoacetyl)-5-methylthiothiophene-2-carboxylate | HCID 86583828 | — |
| Reactant | HCID 178419509 | HCID 178419509 | — |
| Product | HCID 86583842 | HCID 86583842 | 81% |
Reaction Steps
Methyl 4-(2-{[(4-methylphenyl)methyl]amino(1,3-thiazol-4-yl)}-5-methylthiothiophene-2-carboxylate hydrobromide: Methyl 4-(2-bromoacetyl)-5-methylthiothiophene-2-carboxylate (111 mg, 0.35 mmol) was allowed to react with 4-methylphenylmethylthiourea as described in Example 154, step (a) to give 125 mg (81% yield) of methyl 4-(2-{[(4-methylphenyl)methyl]amino}(1,3-thiazol-4-yl))-5-methylthiothiophene-2-carboxylate hydrobromide. Mass Spectrum (ESI) m/z calcd. for C18H18N2O2S2, 358.5 (M+H), found 359.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06515002B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-56bceeb2c1fa4171bd936dcb8c5d7ee7 |
| Source note | uspto-grants-2003_02 |