Ibuprofen, (+-)- → (-)-Camphene

HRID 1058519Notes

Reaction equation

HRID 1058519 reaction equation
[CH:1]12[CH2:10][CH:7]([CH2:8][CH2:9]1)[C:5](=[CH2:6])[C:2]2([CH3:4])[CH3:3].OC(C(C1C=CC(CC(C)C)=CC=1)C)=O>>[CH3:3][C:2]1([CH3:4])[C:5](=[CH2:6])[C@H:7]2[CH2:10][C@@H:1]1[CH2:9][CH2:8]2

Participants

3

Reactant 2

HCID 3672Ibuprofen, (+-)-HCID 6616Camphene2×

Product 1

HCID 440966(-)-Camphene

Procedure

An emulsion of camphene in surfactant solution was prepared as in Example 1 (substituting camphene for ibuprofen). The hot camphene emulsion was pumped (peristaltic pump) at 6 lhr−1 through a cooled coil, to reduce the emulsion temperature to 20° C., then fed directly into a continuous sonication vessel (approximately 30 ml sonicated volume) fitted with a high intensity sonic probe (500 w). Two samples were collected. The first was untreated and the second was cooled rapidly in ice/water. The flow rate was then reduced to 2 lhr−1 and two samples collected and treated as above.

Workup

  1. customto 20° C.
  2. customfed directly into a continuous sonication vessel
  3. custom(approximately 30 ml sonicated volume)
  4. customfitted with a high intensity sonic probe (500 w)
  5. customTwo samples were collected
  6. temperaturethe second was cooled rapidly in ice/water
  7. customcollected
  8. additiontreated as above

Sources & evidence

ORD record
ord-f9f4a792d96f44b081e0575ac6a32b4d
Source dataset
uspto-grants-2003_02
Patent number
US06517853B1

Reaction notes

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