2-Amino-6-(((benzyloxy)carbonyl)amino)hexanoic acid → HCID 13118241, compound

Participants

Reaction Steps

A solution of NaNO2 in water (200 ml) was added dropwise during 3 hr to an ice-cooled and stirred solution of N-ε-CBZ-L-lysine in 1 N H2SO4 and acetonitrile. The mixture was stirred for an additional 2 hr after the addition of 0-5° C. and left to stand overnight. The resulting clear solution was concentrated under reduced pressure. The residual semi-solid was extracted with ether, and the ether extract was then crystallized in ether/petroleum ether. The products recovered was α-(N-CBZ-4-aminobutyl) glycolic acid.

Provenance & Evidence