Acetic Acid → HCID 86613018, compound

HRID 1058522Notes

Reaction equation

[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[C:21]([OH:24])(=[O:23])[CH3:22]>CCCCCC>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[C:21]([O-:24])(=[O:23])[CH3:22]

Participants

Conditions

Temperature: 40 °C

Procedure

Sertraline base, (the compound of Preparation AA, 200 mg) was dissolved in hexane (1.5 mL) in a 10 mL reaction vial. The solution was heated to 40° C. Glacial acetic acid (41.2 μL) was added to the sertraline base solution. The reaction mixture was allowed to cool to room temperature and then granulate for one hour. The solids were filtered and dried in a vacuum oven at 40° C. for 72 hours. The yield was determined to be 90%. mp 126° C.

Workup

temperatureto cool to room temperature
filtrationThe solids were filtered
customdried in a vacuum oven at 40° C. for 72 hours

Sources & evidence

ORD record: ord-0b77b32415454df38668f70fd79ee592
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06517866B1

Reaction notes

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