HRID1058575

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID32153

(1,1'-Biphenyl)-3-acetic acid (9CI)

C14H12O2

HCID74840

Leucine, N-carboxy-, N-benzyl ester, L-

C14H19NO4

HCID83170

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

C11H21NO4

HCID12076055

3-(2-pyridyl)-phenylacetic acid

C13H11NO2

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)CNC(=O)Cc1cccc(-c2ccccc2)c1

HCID69842955

未命名化合物

PROCEDURE

实验过程

Following the procedure of Example 4(a-d), except substituting “Cbz-leucine” for “Boc-leucine” and “3-(phenyl)phenylacetic acid” for “3-(2-pyridyl)phenylacetic acid” gave the title compound: MS (ES+) 530.3 (M+H+), 552.2 (M+Na+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c32c423249234c44a8665575b63b682a
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06518267B1
来源说明: uspto-grants-2003_02

反应 SMILES

[C:1]([NH:11][C@H:12]([C:17]([OH:19])=O)[CH2:13][CH:14]([CH3:16])[CH3:15])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].C([NH:27][C@H:28]([C:33]([OH:35])=O)CC(C)C)(OC(C)(C)C)=O.[C:36]1([C:42]2[CH:43]=[C:44]([CH2:48][C:49]([OH:51])=O)[CH:45]=[CH:46][CH:47]=2)[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1.[N:52]1C=CC=C[C:53]=1C1C=C(CC(O)=O)C=CC=1>>[CH2:4]([O:3][C:1]([NH:11][C@H:12]([C:17]([NH:52][CH2:53][C:33](=[O:35])[CH2:28][NH:27][C:49](=[O:51])[CH2:48][C:44]1[CH:45]=[CH:46][CH:47]=[C:42]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:43]=1)=[O:19])[CH2:13][CH:14]([CH3:15])[CH3:16])=[O:2])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1