Hantzsch ester → HCID 73455757, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of 5-(2-(3,4-dichlorobenzylthio)pyrimidin-4-ylmethylidene)rhodanine (Example 25, 0.3 mmol) in toluene (5 mL) was added diethyl 2,6-dimethyl-1,4-dihydro-3,5-pyridine dicarboxylate (109 mg, 0.39 mmol) and 0.3 g of activated silica gel. The mixture was heated to 80° C. for 20 h then filtered while warm. The filter cake was rinsed with ethyl acetate and the combined filtrates were evaporated to dryness. The residue was redissolved in ethyl acetate and extracted with 1 N aqueous hydrochloric acid. The organic layer was dried (sodium sulfate) and concentrated to give 11 mg of pure product.

Provenance & Evidence