P-Cresol → HCID 18668998, compound

Participants

Reaction Conditions

Reaction Steps

2-Fluoro-5-nitrobenzaldehyde (0.13 g, 0.79 mmol) was dissolved in N,N-dimethylformamide (6.7 mL), and p-cresol (0.22 g, 2.0 mmol) and potassium carbonate (0.27 g, 2.0 mmol) were added thereto, followed by stirring at 25° C. for 1.5 hours. After a conventional treatment, the residue was purified by silica gel chromatography (eluted with chloroform), to obtain 5-nitro-2-(4methylphenoxy)benzaldehyde (0.20 g, 98%).

Provenance & Evidence