4,5-Dichlorophthalic anhydride → 4,5-Dichloro-N-[3-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-phenyl]-phthalamic acid

참여 물질

반응 단계

5-(3-Amino-benzylidene)-thiazolidine-2,4-dione was dissolved in THF and treated with a solution of 4,5-dichlorophthalic anhydride and a catalytic amount of DMAP. The solution was stirred for 8 hours, then filtered and concentrated under vacuum. The residue was dissolved in EtOAc and washed with water. The organic layer was concentrated to an oil and triturated with hexane to give the product as a solid which was collected by filtration.

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