Water → HCID 69940593, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 50 mg (0.09 mmol) of N-[2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-1-oxo-3-phenylpropyl]-L-alanine in 2.5 ml of dichloromethane, cooled to −10° C., is added, under nitrogen, 0.45 ml of boron tribromide as a 1M solution in dichloromethane (0.45 mmol). The mixture is stirred for one hour at −10° C. and then for two hours at a temperature in the region of 20° C. 3 ml of water are added and the dichloromethane is evaporated off. The aqueous phase is washed with diethyl ether and evaporated to dryness. The product is taken up in water and then freeze-dried. 45 mg of product are recovered (yield=100%).

Provenance & Evidence