Methyl L-phenylalaninate hydrochloride → HCID 69939739, compound

HRID 1058766Notes

Reaction equation

HRID 1058766 reaction equation
[OH:1][P:2]([CH2:23][CH:24]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:25](O)=[O:26])([CH:4]([NH:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3].Cl.[NH2:33][C@H:34]([C:42]([O:44][CH3:45])=[O:43])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[OH:3][P:2]([CH2:23][CH:24]([CH2:28][CH:29]([CH3:31])[CH3:30])[C:25]([NH:33][C@H:34]([C:42]([O:44][CH3:45])=[O:43])[CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:26])([CH:4]([NH:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14])[CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:1]

Participants

3

Reactant 2

HCID 75736Methyl L-phenylalaninate hydrochlorideHCID 10994006HCID 10994006, compound

Product 1

HCID 69939739HCID 69939739, compoundYield 65%

Procedure

The process is performed according to the procedure described in 1.8., starting with 250 mg (0.58 mol) of 2-[[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]-4-methylpentanoic acid and 124.5 mg (0.58 mmol) of methyl phenylalaninate hydrochloride. 228 mg of product are recovered (yield=65%).

Workup

  1. custom228 mg of product are recovered (yield=65%)

Sources & evidence

ORD record
ord-92eb4c7535734a74a1cb2ab591edceae
Source dataset
uspto-grants-2003_02
Patent number
US06518260B1

Reaction notes

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