Ethyl 2-(4-bromobenzyl)acrylate → Ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate

HRID 1058771Notes

Reaction equation

HRID 1058771 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[CH2:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[C:16]1([CH2:22][O:23][C:24]([NH:26][CH:27]([PH:29](=[O:31])[OH:30])[CH3:28])=[O:25])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([CH2:15][P:29]([OH:31])([CH:27]([NH:26][C:24]([O:23][CH2:22][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:25])[CH3:28])=[O:30])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12026123Ethyl 2-(4-bromobenzyl)acrylateHCID 178465414HCID 178465414, compound

Product 1

HCID 18668675Ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoateYield 90%

Procedure

The process is performed according to the operating conditions described in 5.3., starting with 2.6 g (9.67 mmol) of ethyl 4-bromo-α-methylenebenzenepropanoate and 2 g (8.23 mmol) of [1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid. 3.79 g of product are recovered (yield=90%).

Workup

  1. custom3.79 g of product are recovered (yield=90%)

Sources & evidence

ORD record
ord-6dcce4bfde6d4080a9258458498d792c
Source dataset
uspto-grants-2003_02
Patent number
US06518260B1

Reaction notes

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