HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylboronic Acid → Ethyl 3-[1,1'-biphenyl]-4-yl-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | Ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate | HCID 18668675 | — |
| Product | Ethyl 3-[1,1'-biphenyl]-4-yl-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate | HCID 18668699 | 97.6% |
Reaction Steps
The process is performed according to the operating conditions in 5.4., starting with 1.7 g (3.32 mmol) of ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate and 4.05 g (3.32 mmol) of phenylboronic acid. 1.65 g of product are recovered (yield=97.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06518260B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-3349035ee4a14cdcaeb3732661193bd0 |
| Source note | uspto-grants-2003_02 |