1,4-Dioxane → HCID 86758839, compound

Participants

Reaction Steps

To the derivatised resin (5), (120 mg) was added 1,4-dioxan (4.5 ml), DIPEA (0.2 ml, 1.2 mmol), water (0.5 ml) and 4-methoxyphenylchloroformate (0.2 ml, 0.6 mmol). The solution was agitated for 12 h at RT then filtered and washed thoroughly with DCM. The resin was treated with 60% trifluoroacetic acid in DCM (1.5 ml) for 3 h with agitation and then filtered. The filtrate was evaporated in vacuo to give the crude product which was purified by preparative HPLC to afford the title compound (2 mg).

Provenance & Evidence