N-(2-Methoxyphenyl)piperazine hydrochloride → HCID 18669098, compound

HRID 1058959Notes

Reaction equation

HRID 1058959 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][CH2:12][C:13]([OH:15])=O.Cl.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([C:13](=[O:15])[CH2:12][CH2:11][C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([CH3:1])[CH:3]=3)[NH:7][CH:6]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 9899402N-(2-Methoxyphenyl)piperazine hydrochlorideHCID 186690955-Methyl-1H-indole-3-propanoic acid

Product 1

HCID 18669098HCID 18669098, compound

Procedure

Prepared from 5-methyl-1H-indole-3-propanoic acid (Description 24) and-(2-methoxyphenyl)piperazine hydrochloride according to the method of Description 25. 1H NMR (360 MHz, CDCl3) δ7.89 (1H, br s), 7.40 (1H, s), 7.24 (1H, d, J 8.3 Hz), 7.04-7.00 (3H, m), 6.94-6.81 (3H, m), 3.86 (3H, s), 3.81 (2H, t, J 5.0 Hz), 3.53 (2H, t, J 5.0 Hz), 3.13 (2H, t, J 7.6 Hz), 2.96 (2H, t, J 5.0 Hz), 2.80 (2H, t, J 5.0 Hz), 2.77-2.73 (2H, m), and 2.46 (3H, s).

Sources & evidence

ORD record
ord-211b2ea816ed41aa8fa3d02b3114e5ea
Source dataset
uspto-grants-2003_02
Patent number
US06518273B1

Reaction notes

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