HCID 18669077, compound → HCID 18669103, compound

HRID 1058967Notes

Reaction equation

HRID 1058967 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[C:5]2[CH2:19][CH2:20][C:21](O)=[O:22].Cl.[F:25][C:26]([F:41])([F:40])[O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]1[CH:13]=[CH:14][C:15]([Cl:18])=[CH:16][CH:17]=1)=[C:5]2[CH2:19][CH2:20][C:21]([N:37]1[CH2:36][CH2:35][N:34]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[O:27][C:26]([F:40])([F:25])[F:41])[CH2:39][CH2:38]1)=[O:22]

Participants

3

Reactant 2

HCID 18669077HCID 18669077, compoundHCID 186690861-[2-(Trifluoromethoxy)phenyl]piperazine hydrochloride

Product 1

HCID 18669103HCID 18669103, compound

Procedure

Prepared from 5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoic acid (Description 12) and 1-[2-(trifluoromethoxy)phenyl]piperazine hydrochloride (Description 19) according to the method of Description 25. 1H NMR (360 MHz, CDCl3) δ7.60 (1H, d, J 1.7 Hz), 7.49 (2H, m), 7.32 (2H, m), 7.24-7.18 (4H, m), 7.04-7.00 (1H, m), 6.93 (1H, dd, J 1.3, 8.0 Hz), 3.71 (2H, t, J 5.0 Hz), 3.54 (3H, s), 3.37 (2H, t, J 5.0 Hz), 3.02 (2H, m), 2.95 (2H, t, J 5.0 Hz), 2.80 (2H, t, J 5.0 Hz), and 2.54 (2H, m). m/z (ES+) 576, 578 (M+1).

Sources & evidence

ORD record
ord-bcbcfac3cd8740b88649e477126c8afc
Source dataset
uspto-grants-2003_02
Patent number
US06518273B1

Reaction notes

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