3,3-Dimethylbutanal → HCID 18669102, compound

HRID 1058977Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[C:5]2[CH2:19][CH2:20][C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22].[CH3:29][C:30]([CH3:35])([CH3:34])[CH2:31][CH:32]=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]1[CH:13]=[CH:14][C:15]([Cl:18])=[CH:16][CH:17]=1)=[C:5]2[CH2:19][CH2:20][C:21]([N:23]1[CH2:24][CH2:25][N:26]([CH2:32][CH2:31][C:30]([CH3:35])([CH3:34])[CH3:29])[CH2:27][CH2:28]1)=[O:22]

Participants

Reactant 2

HCID 763353,3-Dimethylbutanal

HCID 18669066HCID 18669066, compound

Product 1

HCID 18669102HCID 18669102, compound

Procedure

Prepared from 1-{3-[5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indol-3-yl]-1-oxopropyl}piperazine (Description 31) and 3,3-dimethylbutanal according to the method of Example 145. 1NMR (360 MHz, CDCl3) δ7.58 (1H, d, J 1.7 Hz), 7.48 (2H, d, J 6.5 Hz), 7.31 (2H, d, J 6.5 Hz), 7.24 (1H, d, J 8.6 Hz), 7.20 (1H, dd, J 8.6, 1.7 Hz), 3.58 (2H, m), 3.54 (3H, s), 3.23 (2H, m), 2.98 (2H, m), 2.50 (2H, m), 2.33 (2H, m), 2.28 (2H, m), 2.20 (2H, m), 1.37 (2H, m), and 0.90 (9H, s). m/z (ES+) 500, 502 (M+1).

Sources & evidence

ORD record: ord-e125df96fa4b45c391c75b0293afca17
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518273B1

Reaction notes

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