HCID 18669077, compound → HCID 69939504, compound

HRID 1058978Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[C:5]2[CH2:19][CH2:20][C:21](O)=[O:22].[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][C@@H:26]1[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[C:5]2[CH2:19][CH2:20][C:21]([N:28]1[CH2:29][CH2:30][N:25]([CH3:24])[C@@H:26]([CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:27]1)=[O:22]

Participants

Reactant 2

HCID 18669077HCID 18669077, compound

HCID 45115771HCID 45115771, compound

Product 1

HCID 69939504HCID 69939504, compound

Procedure

Prepared from 5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoic acid (Description 12) and (2S)-1-methyl-2-(phenylmethyl)piperazine (Description 35) according to the method of Description 25. 1H NMR (400 MHz, CDCl3) mixture of two amide rotamers; δ7.56-6.98 (12H, m), 4.09, 3.93 (total 1H, each d, J 13.1 Hz), 3.53, 3.47 (total 3H, each s), 3.20-1.98 (12H, m), and 2.39, 2.38 (total 3H, each s). m/z (ES+) 520, 522 (M+1).

Sources & evidence

ORD record: ord-cbf11cea0c7b4401938e51a35e49a6c3
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06518273B1

Reaction notes

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