Sodium borohydride → HCID 86584894, compound

Participants

Reaction Steps

To a solution of 5-(4-chlorophenyl)-6-(4-methanesulfonylphenyl)-4-oxo-4H-pyran-2-carbaldehyde (1.8 g, 4.6 mmoles) in methanol (30 ml), sodium borohydride (0.26 g, 6.9 mmoles)was slowly added at 0° C. The resulting mixture was stirred for 30 minutes at room temperature. The reaction mixture was concentrated and the residue was solved in ethyl acetate. The organic layer was washed with water, dried (Na2SO4), and the solvent was removed under reduced pressure. The resulting residue was purified by column chromatography with silica gel and ethyl acetate/n-hexane (1:1) as eluent. 3-4-chlorophenyl)-6-hydroxymethyl-2-(4-methanesulfonylphenyl)pyran-4-one (0.9 g) was obtained. m.p. 120° C. (Compound 60 in Table 4).

Provenance & Evidence