Hydrochloric Acid → HCID 23563668, compound

Participants

Reaction Steps

(±)-(1S,2S,3R,4R)-2-(t-Butyloxycarbonylamino)-3-(acetamidomethyl)-cyclopentane-1,4-dicarboxylic acid dimethyl ester (255 mg, 0.68 mmole) and lithium hydroxide (2.2 equivalents) in 15 mL of 4:1 methanol:water were reacted at room temperature for 2 hours. The reaction was acidified with dilute HCl and extracted with ethyl acetate (3×60 mL). The organic layers were combined, dried over Na2SO4, filtered and concentrated to provide the title compound.

Provenance & Evidence