HCID 18669678, compound → HCID 18669679, compound

Participants

Reaction Steps

A slurry of 4-[4-(2-aminopyrimidin-5-yl)phenyl]-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-cyclohexen-1-one (1.2 g, 2.63 mmol) in ethyl acetate (20 ml) with palladium on activated carbon (360 mg, 30% w/w) was stirred under hydrogen at atmospheric pressure for three days then filtered and the residue washed with dichloromethane. The combined organic solution was evaporated to afford the title compound as a gray solid (1.05 g, 88% crude yield). 1H-NMR (400 MHz, CDCl3): δ 8.51 (s, 2H), 7.44 (d, 2H, J=8.4), 7.38 (d, 2H, J=8.4), 6.89 (dd, 1H, J=8.4, J=2.2), 6.84 (d, 1H, J=8.4), 6.83 (d, 1H, J=2.2), 5.21 (s, 2H), 4.69 (m, 1H), 3.83(s, 3H), 2.64 (m, 4H), 2.48 (m, 4H). 1.81 (m, 6H), 1.57 (m, 2H).

Provenance & Evidence