Water → N-{2-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]ethyl}-3-methoxybenzamide hydrochloride

Participants

Reaction Steps

The product of Example 1 step (iv) (2.0 g) was dissolved in dichloromethane (490 ml), triethylamine (1.85 ml) and 3-methoxybenzoyl chloride (0.66 g) were added. After 72 hours at room temperature, water was added, the organic phase separated, dried and concentrated to a gum. The product was dissolved in dichloromethane and treated with 1.0M ethereal hydrogen chloride solution to give the titled product as a solid (0.88 g).

Provenance & Evidence