反应详情

The product of Example 10 (0.15 g) was dissolved in dichloromethane (10 ml) and a solution of 1.0M BBr3 in dichloromethane (4 ml) added. After 16 hours at room temperature the solvent was removed by evaporation, methanol was added and the solution concentrated. The residue was dissolved in 2M aqueous HCl solution, concentrated to dryness and the residue triturated under ether to give the titled product as a solid (0.1 g).

1. customAfter 16 hours at room temperature the solvent was removed by evaporation, methanol
2. additionwas added
3. concentrationthe solution concentrated
4. dissolutionThe residue was dissolved in 2M aqueous HCl solution
5. concentrationconcentrated to dryness
6. customthe residue triturated under ether