HCID 131723769, compound → HCID 11447897, compound

Participants

Reaction Steps

Benzyl (2R)-2-cyclohexyl-2-[(2-ethoxy-2-oxoethyl)amino]ethanoate hydrochloride (40 g, 0.1 mol, from step (b) above) dissolved in iso-propyl alcohol (320 mL) was hydrogenated in the presence of 5% Pd/C (2 g, 50% aq.) for 3 h at 30° C. After removal of the catalyst by filtration, the filtrate was neutralised with tetrabutylammonium hydroxide and the pH was adjusted to 5.2. To rid the resultant of water, the suspension was evaporated and washed repeatedly with iso-propylalcohol and dried to yield 49 g (94%) of the sub-title compound.

Provenance & Evidence